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Although tetramethylrhodamine (TMR) maleimides and iodoacetamides are popular thiol-reactive labeling reagents
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation
Alexa Fluor 488 (494Ex/517Em) is a popular green fluorescent dye known for its brightness
1038/s41557-019-0371-1
1038/nature18621
Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4) Size:100mg Although tetramethylrhodamine (TMR) maleimides andSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX
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