Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Size:10mg 0]non-4-yne) is a strained cyclooctyne

0]non-4-yne) is a strained cyclooctyne used in click chemistry for copper-free bioconjugation reactions

Product Name Trametiglue Synonyms CAS Number 2666940-97-0 Related CAS Molecular Formula C25H24FIN6O5S Molecular Weight 666

Product Name NCT 02 Synonyms CAS Number 790245-61-3 Related CAS Molecular Formula C17H16N2O2S Molecular Weight 312

S)-AHPC-CO-PEG4-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C33H49N7O8S Molecular Weight 703

The conventional maleimidocaproyl (MC) unit is replaced by Mal-Propionyl-PEG4 moiety to enhance aqueous solubility

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Size:10mg 0]non-4-yne) is a strained cyclooctyneSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl