Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG8)-PNP Size:100mg 79 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCC#C)C(C)(C)C)C=C1 Purity (HPLC)

79 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCC#C)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

354 SMILES OCCOCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Pure 6-isomer

Product Name Phthalimidinoglutarimide-C6-OH Synonyms Phthalimidinoglutarimide-4'-C6-OH CAS Number n/a Related CAS Molecular Formula C19H24N2O4 Molecular Weight 344

trisulfo CAS Number: N/A Molecular Formula: C35H43N3O10S3 Molecular Weight: 761

Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG8)-PNP Size:100mg 79 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCC#C)C(C)(C)C)C=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating