Thalidomide-5'-piperazine-C2-piperazine HCl e3 GW5074 reduces mHTT levels through

GW5074 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT)

99 SMILES Cl

Also a fluorescent transglutaminase substrate to label proteins by transaminidation

67 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DOTA-tris(t-Bu)ester-PEG6-propargyl Synonyms CAS Number n/a Related CAS Molecular Formula C43H79N5O13 Molecular Weight 874

Thalidomide-5'-piperazine-C2-piperazine HCl e3 GW5074 reduces mHTT levels throughProtein degrader building block. Contains cereblon ligand Thalidomid and 5' substituted heterocyclic linker. Product Name Thalidomide 5' piperazine C2 piperazine HCl Synonyms CAS Number n a Related CAS Molecular Formula C23H33Cl3N6O4 Molecular Weight 563. 91 SMILES Cl. Cl. Cl. O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(=CC=C12)N1CCN(CCN2CCNCC2)CC1 Purity (HPLC) 95% Shipping Conditions Room Temperature Storage Conditions Refrigerated Regulatory Statemen: For