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and drug development
CDCF) can passively diffuse into cells and is colorless and nonfluorescent until the acetate groups are cleaved by intracellular esterases to yield the fluorescent fluorophore
Product Name BC-DBCO Synonyms CLIP-DBCO CAS Number Related CAS Molecular Formula C31H27N5O3 Molecular Weight 517
It is preferred for some complicated biological applications where reproducibility is more critical since the minor positional difference between 5-ROX and 6-ROX might significantly affect some biological properties of the underlying conjugates
6 Purity (HPLC) >= 95% Solubility DMSO
Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE ca and drug developmentSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl
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