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DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP biotin 946 SMILES OC1=C(Br)C=C(\C=C2/C(=O)NC3=C2C=C(I)C=C3)C=C1Br Purity (HPLC)

SKU 82124436642
4.2
USD345.00 USD372.00

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Description

946 SMILES OC1=C(Br)C=C(\C=C2/C(=O)NC3=C2C=C(I)C=C3)C=C1Br Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Product Name Phthalimidinoglutarimide-propargyl-C1-amine HCl Synonyms Phthalimidinoglutarimide-4'-propargyl-C1-amine HCl CAS Number 2138440-40-9 Related CAS Molecular Formula C17H18ClN3O3 Molecular Weight 347

261 SMILES BrCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

058 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

This ADC building block is widely used in the synthesis of antibody-drug conjugates for cancer research

DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP biotin 946 SMILES OC1=C(Br)C=C(\C=C2/C(=O)NC3=C2C=C(I)C=C3)C=C1Br Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing

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