HQ461 deuterium-labeled-ketone 2 SMILES: OC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC(Cl)=C(O)C=C2OC2=C1C=C(Cl)C(O)=C2

2 SMILES: OC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC(Cl)=C(O)C=C2OC2=C1C=C(Cl)C(O)=C2

168 SMILES [2H]C([2H])([2H])OC1=CC=C(C=C1)C#N Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Pomalidomide-PEG2-C2-azide Synonyms Pomalidomide-4'-PEG2-C2-azide CAS Number 2271036-45-2 Related CAS Molecular Formula C19H22N6O6 Molecular Weight 430

68 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCO)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Texas Red PEG3 azide Synonyms Sulforhodamine 101 PEG3 azide CAS Number N/A Related CAS Molecular Formula C39H46N6O9S2 Molecular Weight 806

HQ461 deuterium-labeled-ketone 2 SMILES: OC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC(Cl)=C(O)C=C2OC2=C1C=C(Cl)C(O)=C2HQ461 is a molecular glue that promotes CDK12 DDB1 interaction to trigger cyclin K degradation. HQ461 mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. Product Name HQ461 Synonyms CAS Number 1226443 41 9 Related CAS Molecular Formula C15H15N5OS2 Molecular Weight 345. 44 SMILES CC1=CN=C(NC(=O)CC2=CSC(NC3=NC(C)=CC=C3)=N2)S1 Purity