Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:1mg 75 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCC(O)=O)C(C)(C)C)C=C1 Purity (HPLC)

75 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCC(O)=O)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DOTA-tris(t-Bu)ester-C2-alcohol Synonyms CAS Number n/a Related CAS Molecular Formula C30H57N5O8 Molecular Weight 615

11 Purity (HPLC) >= 95% Solubility DMSO

Product Name 1-[2-(piperazin-1-yl)ethyl]piperazine Synonyms CAS Number 19479-83-5 Related CAS Molecular Formula C10H22N4 Molecular Weight 198

42 SMILES Cl

Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:1mg 75 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCC(O)=O)C(C)(C)C)C=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent