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specifically used in the strain-promoted azide-alkyne cycloaddition (SPAAC) reaction
Product Name DOTA-NHS Synonyms CAS Number 170908-81-3 Related CAS Molecular Formula C20H31N5O10 Molecular Weight 501
Product Name Phthalimidinoglutarimide-C5-Br Synonyms Phthalimidinoglutarimide-4'-C5-Br CAS Number n/a Related CAS Molecular Formula C18H21BrN2O3 Molecular Weight 393
linking two molecules covalently
Product Name Pomalidomide-CO-C2-alkyne Synonyms Pomalidomide-4'-CO-C2-alkyne CAS Number 2408797-68-0 Related CAS Molecular Formula C18H15N3O5 Molecular Weight 353
Azide-Hexanoyl-Val-Ala-PAB(m-PEG8)-Exatecan acid-acid specifically used in the strain-promotedSOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC
