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which recruit the VHL or CRBN-ubiquitin E3 ligases to induce the degradation of CLIP-fusion proteins
It’s a bifunctional molecule featuring a chloroalkane group (specific for HaloTag) and an O6-benzylguanine (BG) derivative (specific for SNAP-tag)
CA-PEG4-Azide can be used to attach azide moiety to protein
058 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
demonstrating a DC50 of 19 nM against GFP-HaloTag7 fusion proteins
Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg which recruit the VHL orSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage
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