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517 Purity (HPLC) >= 95% Solubility DMSO
It reacts with primary amines via carbodiimide activation of the carboxylic acid
The strain in DBCO’s cyclooctyne ring drives the reaction forward by releasing energy when it transitions to the triazole product
348 SMILES OC(=O)CCOCCOC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
SJ6986 has very good oral bioavailability (F = 84% in mice)
DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan aldehyde 517 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further
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