Mal-Propionyl-PEG4-Val-Ala-PAB(m-PEG4)-MMAE Size:10mg 458 SMILES CC(C)(C)OC(=O)CN1CCN(CCN2CCNCC2)CC1 Purity (HPLC)

458 SMILES CC(C)(C)OC(=O)CN1CCN(CCN2CCNCC2)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

76 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCC#C)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Acetyl-CA CAS Number Related CAS Molecular Formula C12H24ClNO3 Molecular Weight 265

resulting in turn-on fluorescence

086 Purity (HPLC) >= 95% Solubility DMSO

Mal-Propionyl-PEG4-Val-Ala-PAB(m-PEG4)-MMAE Size:10mg 458 SMILES CC(C)(C)OC(=O)CN1CCN(CCN2CCNCC2)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly