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Sci Transl Med 2021
Product Name DOTA-tris(t-Bu)ester-C5-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C40H69N7O10 Molecular Weight 808
CA-SS-SiR is a cleavable HaloTag ligand featuring a disulfide bond that can be cleaved using a reducing agent
Product Name DOTA-tris(t-Bu)ester-C2-amine Synonyms CAS Number 173308-19-5 Related CAS Molecular Formula C30H58N6O7 Molecular Weight 614
338 SMILES OCCOCCOC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE exatecan Sci Transl Med 2021SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is
