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388 Purity (HPLC) >= 95% Solubility DMSO
Product Name Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Synonyms CAS Number Related CAS Molecular Formula C63H96N10O26 Molecular Weight 1409
Nature 2016
PEG3 linker enhances water solubility and provides spatial separation to minimize steric hindrance during binding interactions
making the linkers highly adaptable for diverse ADC and related applications
Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:10mg 388 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a
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