Propargyl-Acetyl-Val-Ala-PAB(m-PEG8)-MMAE Size:25mg 48 SMILES Cl

48 SMILES Cl

Journal of the American Chemical Society

6-TAMRA cadaverine is the other purified single isomer of 5(6)-TAMRA cadaverine mixture

Product Name DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C60H85N7O16 Molecular Weight 1160

Contains an E3 ligase ligand substituted with piperazine

Propargyl-Acetyl-Val-Ala-PAB(m-PEG8)-MMAE Size:25mg 48 SMILES ClSOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing