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Signal Transduction and Targeted Therapy
The inhibiting SHP2 activity of SHP099 is through an allosteric mechanism
Product Name DOTA-C3-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C26H41N7O10 Molecular Weight 611
351 SMILES OCCOCC#CC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name 1-bromo-2-(methoxy-d3)benzene Synonyms 1-bromo-2-(²H3)methoxybenzene CAS Number 892397-56-7 Related CAS Molecular Formula C7H7BrO Molecular Weight 190
Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan pab Signal Transduction and Targeted TherapySOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is
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