Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP 5' 722 SMILES: [O-]C(=O)C1=CC=C(C=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N

722 SMILES: [O-]C(=O)C1=CC=C(C=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N

Product Name Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Synonyms CAS Number Related CAS Molecular Formula C63H97N9O25 Molecular Weight 1380

Product Name Pomalidomide-PEG2-C2-amine HCl Synonyms Pomalidomide-4'-PEG2-C2-amine HCl CAS Number 2245697-87-2 Related CAS 2093416-32-9 (free base) Molecular Formula C19H25ClN4O6 Molecular Weight 440

Suitable for use in TR-FRET

Degrader building block for targeted protein degradation

Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP 5' 722 SMILES: [O-]C(=O)C1=CC=C(C=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#NSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para