Mal-Propionyl-PEG2-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:25mg 968 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

968 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Thalidomide-O-PEG1-C2-acid Synonyms Thalidomide-4'-O-PEG1-C2-acid CAS Number n/a Related CAS Molecular Formula C18H18N2O8 Molecular Weight 390

especially those targeting lysine side-chain modifications

Product Name Mal-Acetyl-Beta-Ala-Gly-Gly-Phe-Gly-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C49H70N8O18 Molecular Weight 1059

Abstract S6-04: The PI3K inhibitor

Mal-Propionyl-PEG2-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:25mg 968 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a