Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg 579 SMILES O=C1N(CC2=C(NCCOCCOCCOCCOCCOCC#C)C=CC=C12)C1CCC(=O)NC1=O Purity (HPLC)

579 SMILES O=C1N(CC2=C(NCCOCCOCCOCCOCCOCC#C)C=CC=C12)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Phthalimidinoglutarimide-C3-Br Synonyms Phthalimidinoglutarimide-4'-C3-Br CAS Number n/a Related CAS Molecular Formula C16H17BrN2O3 Molecular Weight 365

SiR-6-COOH (652Ex/674Em) is a single-isomer carboxylic acid derivative that can be conjugated to amine-containing molecules

523 SMILES OC(=O)CCOCCOCCOCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C64H80FN9O19 Molecular Weight 1298

Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg 579 SMILES O=C1N(CC2=C(NCCOCCOCCOCCOCCOCC#C)C=CC=C12)C1CCC(=O)NC1=O Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,