Mal-Propionyl-PEG8-Val-Ala-PAB(m-PEG4)-Exatecan Thalidomide 352 SMILES [N-]=[N+]=NCCCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

352 SMILES [N-]=[N+]=NCCCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name CA-TCO Synonyms TCO-Halo

Compared to earlier iterations

32 Purity (HPLC) >= 95% Solubility DMSO

Product Name Thalidomide-O-C5-OH Synonyms Thalidomide-4'-O-C5-OH CAS Number 2411099-10-8 Related CAS Molecular Formula C18H20N2O6 Molecular Weight 360

Mal-Propionyl-PEG8-Val-Ala-PAB(m-PEG4)-Exatecan Thalidomide 352 SMILES [N-]=[N+]=NCCCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I