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MC-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:10mg Product Name Thalidomide-5'-piperazine-C2-OH Synonyms CAS

SKU 1501120196
4.7
EUR495.00 EUR522.00

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Description

Product Name Thalidomide-5'-piperazine-C2-OH Synonyms CAS Number 2222115-00-4 Related CAS Molecular Formula C19H22N4O5 Molecular Weight 386

Haven’t got a glue: Protein surface variation for the design of molecular glue degraders

S)-AHPC-CO-C2-piperazine HCl Synonyms CAS Number n/a Related CAS Molecular Formula C29H44Cl2N6O4S Molecular Weight 643

Product Name DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C60H85N7O16 Molecular Weight 1160

372 SMILES OCCCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

MC-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:10mg Product Name Thalidomide-5'-piperazine-C2-OH Synonyms CASSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers

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