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Mal-Acetyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB amine-amine Coumarin hydrazine is an aromatic

Description

Coumarin hydrazine is an aromatic hydrazine-containing fluorophores that reacts with aldehyde or ketones for fluorescent labeling

71 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCC#C)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

1038/s41589-020-0594-x

1126/sciadv

127 Purity (HPLC) >= 95% Solubility DMSO

Mal-Acetyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB amine-amine Coumarin hydrazine is an aromaticSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or

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